Qingyi granules ameliorate severe acute pancreatitis in rats by modulating the gut microbiota and serum metabolic aberrations

Autor:	Juying Jiao, Jianjun Liu, Fei Luo, Mengxue Shang, Chen Pan, Bing Qi, Liang Zhao, Peiyuan Yin, Dong Shang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Traditional Chinese medicine emodin inflammatory response microbiome metabolome Therapeutics. Pharmacology RM1-950
Zdroj:	Pharmaceutical Biology, Vol 61, Iss 1, Pp 927-937 (2023)
Druh dokumentu:	article
ISSN:	13880209 1744-5116 1388-0209
DOI:	10.1080/13880209.2023.2222755
Popis:	AbstractContext Qingyi granules can be used to effectively treat patients with severe acute pancreatitis (SAP).Objective To elucidate the role of gut microbiota-mediated metabolism in the therapeutic effects of Qingyi granules.Materials and methods Sprague–Dawley rats were grouped into the sham operation, SAP model, Qingyi granule intervention (Q, 1.8 g/kg) and emodin intervention (E, 50 mg/kg) groups and observed for 24 h. H&E staining and ELISA were used for histopathological analysis and serum enzyme and cytokine assays. 16S rDNA sequencing and UHPLC-HRMS were used for gut microbiota analysis and untargeted metabolomics.Results In SAP rats, Qingyi granules decreased the pancreatic pathological score (Q, 7.4 ± 1.14; SAP, 11.6 ± 1.14, p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ca040061204645029d38ab183c102ece Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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