Cellular regulation of the structure and function of aortic valves
Autor: | Ismail El-Hamamsy, Adrian H. Chester, Magdi H. Yacoub |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: | |
Zdroj: | Journal of Advanced Research, Vol 1, Iss 1, Pp 5-12 (2010) |
Druh dokumentu: | article |
ISSN: | 2090-1232 2090-1224 |
DOI: | 10.1016/j.jare.2010.02.007 |
Popis: | The aortic valve was long considered a passive structure that opens and closes in response to changes in transvalvular pressure. Recent evidence suggests that the aortic valve performs highly sophisticated functions as a result of its unique microscopic structure. These functions allow it to adapt to its hemodynamic and mechanical environment. Understanding the cellular and molecular mechanisms involved in normal valve physiology is essential to elucidate the mechanisms behind valve disease. We here review the structure and developmental biology of aortic valves; we examine the role of its cellular parts in regulating its function and describe potential pathophysiological and clinical implications. |
Databáze: | Directory of Open Access Journals |
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