Cellular regulation of the structure and function of aortic valves

Autor:	Ismail El-Hamamsy, Adrian H. Chester, Magdi H. Yacoub
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Aortic valve Endothelium Mechanotransduction Aortic valve calcification Interstitial cells Medicine (General) R5-920 Science (General) Q1-390
Zdroj:	Journal of Advanced Research, Vol 1, Iss 1, Pp 5-12 (2010)
Druh dokumentu:	article
ISSN:	2090-1232 2090-1224
DOI:	10.1016/j.jare.2010.02.007
Popis:	The aortic valve was long considered a passive structure that opens and closes in response to changes in transvalvular pressure. Recent evidence suggests that the aortic valve performs highly sophisticated functions as a result of its unique microscopic structure. These functions allow it to adapt to its hemodynamic and mechanical environment. Understanding the cellular and molecular mechanisms involved in normal valve physiology is essential to elucidate the mechanisms behind valve disease. We here review the structure and developmental biology of aortic valves; we examine the role of its cellular parts in regulating its function and describe potential pathophysiological and clinical implications.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/03fb0bf6fbd64863baaa2ab5d58b7eef Zobrazit plný text záznamu View record in DOAJ