Unrelated Allogeneic Stem Cell Transplantation in a Patient with Chronic Myeloid Leukemia in Blast Crisis

Autor: Benedek István, Lázár Erzsébet, Köpeczi Judit Beáta, Tunyogi Aliz Beáta, Jakab Szende, Pakucs Annamária
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Interdisciplinary Medicine, Vol 2, Iss 2, Pp 160-163 (2017)
Druh dokumentu: article
ISSN: 2501-8132
DOI: 10.1515/jim-2017-0049
Popis: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder, which can involve the hematopoietic stem cell or early progenitor cells, without the loss of their capacity to differentiate. Typically, CML has three clinical phases: a chronic phase, an accelerated phase, and an aggressive transformation in blast crisis, analogous to acute leukemia. The following article presents the case of a 49-year-old patient diagnosed with Philadelphia-negative CML in blastic transformation, where after multiple conventional acute leukemia induction chemotherapy regimens an unrelated allogeneic hematopoietic stem cell transplant was performed.
Databáze: Directory of Open Access Journals