| Autor: |
Yongyan Peng, Sarah B. Cordiner, Gregory M. Sawyer, Tony K. McGhie, Richard V. Espley, Andrew C. Allan, Roger D. Hurst |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 65, Iss , Pp 103734- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2019.103734 |
| Popis: |
Asthma is an allergic lung inflammation characterised by the influx of eosinophils at the infected site recruited by the chemokine, CCL11. During inflammation, the transcription factor Nuclear Factor kappa B (NF-κB) initiates a series of pro-inflammatory responses. Natural compounds that could modulate CCL11 levels and/or NF-κB activation have potential for managing lung inflammation. In this study, four varieties of kiwifruit were evaluated for their modulatory effect on inflammation signals. The anthocyanin-enriched polyphenol extracts from purple kiwifruit inhibited CCL11 secretion from human alveolar epithelial cells whereas the anthocyanin-lacking polyphenol extracts from yellow kiwifruit displayed no inhibition on CCL11 secretion. Kiwifruit polyphenol extracts also inhibited NF-κB activation in reporter cells. Correlation analysis showed anthocyanins in the kiwifruit polyphenolic extracts were most correlated to the modulation of CCL11 and NF-κB which are the inflammatory signals involved in lung allergic inflammation. The findings highlight the enhanced functional food benefits of novel kiwifruit cultivars. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect