Three-Step Synthesis of N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide from 4,7-Dichloroquinoline

Autor:	Deiby F. Aparicio Acevedo, Marlyn C. Ortiz Villamizar, Vladimir V. Kouznetsov
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	4 7-dichloroquinoline N-oxides C–H bond functionalization C2-amide formation reaction C4 SNAr reaction N-(quinolinyl)morpholines Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2024, Iss 1, p M1796 (2024)
Druh dokumentu:	article
ISSN:	1422-8599
DOI:	10.3390/M1796
Popis:	The quinoline derivative, N-(7-chloro-4-morpholinoquinolin-2-yl)benzamide, was synthesized in a conventional three-step procedure from 4,7-dichloroquinoline using a N-oxidation reaction/C2-amide formation reaction/C4 SNAr reaction sequence. The structure of the compound was fully characterized by FT-IR, 1H-, 13C-NMR, DEPT-135°, and ESI-MS techniques. Its physicochemical parameters (Lipinski’s descriptors) were also calculated using the online SwissADME database. Such derivatives are relevant therapeutic agents exhibiting potent anticancer, antibacterial, antifungal, and antiparasitic properties.
Databáze:	Directory of Open Access Journals
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