Rationale and Design of a Prospective, Multicenter, Observational Study Evaluating Iron Deficiency in Patients Hospitalized for Heart Failure (FERIC-RO)

Autor: Antohi Elena Laura, Chitoiu Gabriel Tatu, Ambrosy Andrew P, Coman Ioan M, Vinereanu Dragos, Collins Sean P, Sinescu Crina, Mihaileanu Serban, Pang Peter S, Butler Javed, Chioncel Ovidiu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Romanian Journal of Laboratory Medicine, Vol 26, Iss 3, Pp 271-281 (2018)
Druh dokumentu: article
ISSN: 2284-5623
DOI: 10.2478/rrlm-2018-0022
Popis: Introduction: Several landmark studies, which enrolled heart failure (HF) patients who were ambulatory at the time of inclusion, identified iron deficiency (ID) as an important therapeutic target: intravenous iron administration with ferric carboxymaltose (FCM) improves morbidity, exercise capacity, and quality of life in patients with HF and reduced EF (HFrEF). However, there is still limited knowledge about ID prevalence during hospitalization for Worsening Chronic HF (WCHF) and about the relationship between ID during hospitalization and post-discharge outcomes. Although previous studies documented ID as an independent risk factor for poor outcomes in HFrEF, its prognostic significance in HF patients with EF>40% remains unclear.
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