Deep phenotyping unveils hidden traits and genetic relations in subtle mutants

Autor: Adriana San-Miguel, Peri T. Kurshan, Matthew M. Crane, Yuehui Zhao, Patrick T. McGrath, Kang Shen, Hang Lu
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12990
Popis: Experimenter scoring of cellular imaging data can be biased. This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans.
Databáze: Directory of Open Access Journals