| Autor: |
D. Yu. Semyonov, Z. H. Osmanov, A. G. Tonoyan, L. G. Shapkina, A. V. Sokolov, M. V. Gorchakova |
| Jazyk: |
ruština |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Вестник хирургии имени И.И. Грекова, Vol 173, Iss 1, Pp 044-046 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
0042-4625 |
| DOI: |
10.24884/0042-4625-2014-173-1-044-046 |
| Popis: |
The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers. A correlated analysis was made between obtained results of laboratory and instrumental researches and clinical course of acute pancreatitis. The decrease of MT1 receptors expression was noted on 25% in patients with acute pancreatitis. The decline of MT2 receptors expression was observed on 40% of patients with acute severe pancreatitis and in a case of acute mild pancreatitis — on 15,5%, respectively. Values of MT1 and MT2 expression were equal between healthy volunteers. The decline of MT2 expression was a prognostic unfavourable sign. Obtained results of dynamic expression assessment of MT-receptors were presented as MT2/MT1 indices. Given index didn’t change during disease, because of this, the index could be used as a prognostic development marker of destructive form of acute pancreatitis at the moment of patient’s admission to hospital. Mean values of MT2/MT1 were determined for the purpose of universalization of used method (1,13±0,09 for mild form and 0,81±0,09 for severe form of acute pancreatitis, respectively). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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