Indole-3-propionic acid enhances growth performance and reduces diarrhea via modulating redox status and intestinal inflammation in weaned piglets

Autor: Dongxu Ming, Xincong Xu, Xianren Jiang, Yanpin Li, Wenjuan Sun, Jiangbo Xiang, Mingyuan Huang, Yu Pi, Xilong Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Animal Nutrition, Vol 19, Iss , Pp 240-247 (2024)
Druh dokumentu: article
ISSN: 2405-6545
DOI: 10.1016/j.aninu.2024.08.004
Popis: Indole-3-propionic acid (IPA) has anti-inflammatory properties, which can be beneficial for weaned piglets with underdeveloped immune systems. The study explores the impact of IPA supplementation on growth performance, oxidative stress, and inflammation response in weaned piglets. In Exp. 1, 90 weaned piglets were divided into six groups (5 replicates per group, 3 pigs per replicate), with each group receiving a basal diet with varying amounts of IPA (0, 50, 100, 200, 400, or 600 mg/kg) for 42 d. Piglets fed the diets with 50, 100, and 200 mg/kg of IPA exhibited reduced feed conversion ratios (F:G) compared to the control piglets (P = 0.035). Notably, 50 and 100 mg/kg IPA treatments significantly reduced diarrhea incidence and serum interleukin (IL)-6 content (P
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