Comparing Myo-Inositol and Folic Acid with and without D-Chiro-Inositol for The Management of Polycystic Ovary Syndrome
| Autor: | Reja Akram, Saghir Ahmed Jafri, Shahida Malik, Sameena Nisar, Amna Irum |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Pakistan Journal of Medicine and Dentistry, Vol 13, Iss 4 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2313-7371 2308-2593 |
| DOI: | 10.36283/ziun-pjmd13-4/011 |
| Popis: | Background: Polycystic ovarian syndrome (PCOS) is an endocrinological disease of women of the reproductive age group. The study aimed to compare the efficacy of Myo-inositol and folic acid with and without D-chiro-inositol in the improvement of symptoms of PCOS within 4 months for the evaluation of the most effective therapeutic regimen. Methods: This Quasi-experimental study was conducted at Gynecology & Obstetrics OPD of two Private Healthcare Hospitals in Sialkot from February 2024-June 2024. The Rotterdam criteria (2003) was used for diagnosis of PCOS in non-pregnant women aged between 18-35 years. A total of 90 PCOS patients (45 in each group) were enrolled using a purposive sampling technique and distributed into two treatment groups. Group A received MI 2000 mg + DCI 50 mg + FA 200 mcg while Group B received MI 2000 mg + FA 200 mcg BD, after meal, for 17-18 weeks. Patients’ menstrual cycle history, BMI, transabdominal-ultrasonographic picture, and serum total testosterone levels were evaluated at Day 0, 60, and 120 to compare these measurements before and after initiation of treatment. SPSS was used to analyze the data. Independent samples t-test and Repeated measures ANOVA were used to analyze the data. P-value ≤ 0.05 was considered statistically significant. Results: After the intervention, body mass index (kg/m²), serum total testosterone levels (ng/dl), and follicular number per ovary decreased, with Group A demonstrating better performance with p-values 0.03, 0.04, and < 0.001 respectively. Both groups exhibited increased follicular size in both ovaries and decreased ovarian volumes. By Day 120, menstrual cycle regularity was more pronounced in Group A than in Group B (1.00 ± 0.00 and 1.13 ± 0.34 respectively, p-value |
| Databáze: | Directory of Open Access Journals |
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