Growth Hormone and Disease Severity in Early Stage of Multiple Sclerosis
| Autor: | M. Gironi, C. Solaro, C. Meazza, M. Vaghi, L. Montagna, M. Rovaris, A. P. Batocchi, R. Nemni, R. Albertini, M. Zaffaroni, M. Bozzola |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Multiple Sclerosis International, Vol 2013 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2090-2654 2090-2662 |
| DOI: | 10.1155/2013/836486 |
| Popis: | Evidence suggests that neurohormones such as GH and IGF-I are involved in the neuroreparative processes in multiple sclerosis (MS). GH and IGF-I blood levels in naïve MS patients with different disease courses were investigated in this study. Serum GH and IGF-I in untreated MS patients (n=64), healthy controls (HC, n=62), and patients affected by other neurological diseases (OND, n=46) were evaluated with a solid-phase-enzyme-labeled-chemiluminescent-immunometric assay. No differences were detected in GH across MS, OND, and HC (MS=0.87±1.32 ng/mL; OND=1.66±3.7; and HC=1.69±3.35; P=0.858) when considering gender, disease duration, and disease course. However, GH was lower (P=0.007) in patients with more severe disease (expanded disability scale score, EDSS≥4.0) compared with milder forms (EDSS |
| Databáze: | Directory of Open Access Journals |
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