Supramolecular trap for catching polyamines in cells as an anti-tumor strategy

Autor: Junyi Chen, Hanzhi Ni, Zhao Meng, Jing Wang, Xiayang Huang, Yansheng Dong, Chao Sun, Yadan Zhang, Lei Cui, Jian Li, Xueshun Jia, Qingbin Meng, Chunju Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-11553-7
Popis: Polyamines are essential for cell growth and are frequently increased in concentration in cancer cells. Here, the authors use a macrocycle to generate a supramolecular trap, which depletes the polyamines in cells, induces apoptosis and reduces cancer cell growth in mice.
Databáze: Directory of Open Access Journals