Overnight desaturation in interstitial lung diseases: links to pulmonary vasculopathy and mortality
| Autor: | George A. Margaritopoulos, Athanasia Proklou, Athina Trachalaki, Diana Badenes Bonet, Maria Kokosi, Vasilis Kouranos, Felix Chua, Peter George, Elisabetta A. Renzoni, Anand Devaraj, Sujal Desai, Andrew G. Nicholson, Katerina M. Antoniou, Athol U. Wells |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 10, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00740-2023 |
| Popis: | Background Overnight desaturation predicts poor prognosis across interstitial lung diseases (ILDs). The aim of the present study was to investigate whether nocturnal desaturation is associated with pulmonary vasculopathy and mortality. Methods A retrospective single centre study of 397 new ILD patients was carried out including patients with idiopathic pulmonary fibrosis (IPF) (n=107) and patients with non-IPF fibrotic ILD (n=290). This is the largest study to date of the effect of significant nocturnal desaturation (SND) (≥10% of total sleep time with oxygen saturation ≤90% measured by pulse oximetry). Results The prevalence of SND was 28/107 (26.2%) in IPF and 80/290 (27.6%) in non-IPF ILD. The prevalence of SND was higher in non-IPF ILDs than in IPF (p=0.025) in multivariate analysis. SND was associated with noninvasive markers of pulmonary hypertension (PH): tricuspid regurgitation velocity (TRV) (p4% in 6-min walking test (p |
| Databáze: | Directory of Open Access Journals |
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