Translation and validation of the Neurological Assessment in Neuro-Oncology scale to Brazilian Portuguese

Autor: Maíra Cristina Velho, Daniel Andrade Gripp, Paulo Henrique Pires de Aguiar, Joab Alves Nicacio, Cleiton Formentin, Gabriel Frizon Greggianin, Ana Carolina Pinheiro Campos, Marcos Vinicius Calfat Maldaun
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Neurology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-2295
DOI: 10.3389/fneur.2024.1369625
Popis: IntroductionThe Neurological Assessment for Neuro-Oncology (NANO) scale was elaborated to assess neurologic function in integration with radiological criteria to evaluate neuro-oncological patients in clinical setting and enable the standardization of neurological assessment in clinical trials. The objective of this study is the translation to Brazilian Portuguese and transcultural adaptation of NANO scale in patients with the diagnosis of glioblastoma, brain metastasis and low-grade glioma.MethodsPatients with diagnosis of glioblastoma, brain metastasis, and low-grade glioma were prospectively evaluated between July 2019 and July 2021. The process of translating and cross-culturally adapting the NANO scale included: translation from English to Portuguese, synthesis and initial revision by an expert committee, back-translation from Portuguese to English, a second revision by the expert committee, and the application of the NANO scale. Regarding the reliability of the NANO scale, Cronbach’s alpha was employed to measure the internal consistency of all scale items and assess the impact of item deletion. Additionally, Spearman’s correlation test was used to evaluate the convergent validity between the NANO scale and Karnofsky Performance Scale (KPS).ResultsOne hundred and seventy-four patients were evaluated. A statistically significant inverse relation (p
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