Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction
| Autor: | T. A. Denisyuk, M. V. Pokrovsky, G. A. Lazareva, T. G. Pokrovskaya, M. V. Korokin, O. A. Osipova, A. I. Lazarev, L. N. Sernov, S. A. Demchenko |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Кубанский научный медицинский вестник, Iss 1, Pp 30-34 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1608-6228 2541-9544 |
| Popis: | Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective effects, manifested in preventing the proliferation of coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and normalization values of biochemical markers (Total NO, Expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy found no additive effect of drugs. |
| Databáze: | Directory of Open Access Journals |
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