The role of OFD1 in selective autophagy
| Autor: | Brunella Franco, Manuela Morleo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Molecular & Cellular Oncology, Vol 8, Iss 3 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2372-3556 23723556 |
| DOI: | 10.1080/23723556.2021.1903291 |
| Popis: | Autophagy is a cellular self-degradative pathway. Our study unveiled a novel mechanism mediated by OFD1, the protein mutated in Oral-Facial-Digital type I syndrome, based on selective degradation of autophagic proteins, which enables cells to calibrate their self-degradation. We demonstrated that unrestrained autophagy contributes to renal cysts observed in Ofd1 mutants. |
| Databáze: | Directory of Open Access Journals |
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