Post-covid Multisystem Inflammatory Syndrome in children (Mis-C) with rare gastrointestinal ramifications: Case reports from a Tertiary Care Hospital in Eastern India

Autor: Sanjay Kumar Sahu, Soumya Ranjan Mohapatra, Sushant Kumar Das, Ravi Kumar, Nirmal Kumar Mohakud
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 15, Iss 8, Pp 348-352 (2022)
Druh dokumentu: article
ISSN: 2589-8302
2589-8310
DOI: 10.4103/mjdrdypu.mjdrdypu_320_22
Popis: Children with prior coronavirus disease 2019 (COVID-19) infection display an increased systemic inflammation causing multiorgan dysfunctions in the cardiovascular, respiratory, central nervous system, and gastrointestinal (GI) systems, known as MIS-C, that is, multisystem inflammatory syndrome in children. Most of the MIS-C cases have GI manifestations like pain abdomen, loose motion, vomiting or nausea, elevated liver enzymes, ileus, and bleeding. Angiotensin-converting enzyme 2 (ACE2) receptors in the terminal ileum and colon are responsible for the majority of ACE2-induced damage to these tissues. In the pandemic's second wave, a significant number of MIS-C patients with predominantly GI symptoms (around 80%) were reported. Although different molecular inflammatory mechanisms are involved, there is a significant overlap of the children's GI symptoms with those of MIS-C and other conditions of the abdomen caused by infection or inflammation, thus resulting in a diagnostic dilemma. Here, we report two cases of MIS-C with acute appendicular perforation and ileal perforation needing both medical management and surgical intervention.
Databáze: Directory of Open Access Journals
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