Mechanism of intestinal microbiota disturbance promoting the occurrence and development of esophageal squamous cell carcinoma——based on microbiomics and metabolomics

Autor:	Xingqiang Huang, Xueyi Chen, Guowei Wan, Dandan Yang, Dongqiang Zhu, Linqian Jia, Jinping Zheng
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Esophageal squamous cell carcinoma Gut microbiota Metabolomics Mechanism of carcinogenesis Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 24, Iss 1, Pp 1-17 (2024)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-024-11982-8
Popis:	Abstract Esophageal squamous cell carcinoma (ESCC) is a high-risk malignant tumor that has been reported in China. Some studies indicate that gut microbiota disorders can affect the occurrence and development of ESCC, but the underlying mechanism remains unclear. In this study, we aimed to explore the possible underlying mechanisms using microbiomics and metabolomics. Fifty ESCC patients and fifty healthy controls were selected as the study subjects according to sex and age, and fecal samples were collected. 16S rDNA sequencing and LC‒MS were used for microbiomics and nontargeted metabolomics analyses. We found significant differences in the composition of the gut microbiota and metabolites between the ESCC patients and control individuals (P
Databáze:	Directory of Open Access Journals
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