Planar aggregation of the influenza viral fusion peptide alters membrane structure and hydration, promoting poration

Autor: Amy Rice, Sourav Haldar, Eric Wang, Paul S. Blank, Sergey A. Akimov, Timur R. Galimzyanov, Richard W. Pastor, Joshua Zimmerberg
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34576-z
Popis: Target membrane poration is a longstanding enigma in virology. Here, authors show that fusion peptides of the influenza virus’ spike protein aggregate, rotate, and tilt in membranes, facilitating peptide-induced poration during viral fusion.
Databáze: Directory of Open Access Journals