Improved Solubility and Dissolution Rates in Novel Multicomponent Crystals of Piperine with Succinic Acid
| Autor: | Erizal Zaini, Afriyani, Lili Fitriani, Friardi Ismed, Ayano Horikawa, Hidehiro Uekusa |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Scientia Pharmaceutica, Vol 88, Iss 2, p 21 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2218-0532 0036-8709 |
| DOI: | 10.3390/scipharm88020021 |
| Popis: | The objectives of this study were to prepare and characterize a novel piperine–succinic acid multicomponent crystal phase and to evaluate the improvement in the solubility and dissolution rate of piperine when prepared in the multicomponent crystal formation. The solid-state characterization of the novel multicomponent crystal was performed by powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform-infrared (FT-IR) spectroscopy. Solubility and dissolution rate profiles were evaluated in distilled water. The physical stability was evaluated under high relative humidity (75% and 100% RH). The determination of the single crystal X-ray diffraction structure revealed that this novel multicomponent crystal was a cocrystalline phase of piperine–succinic acid (2:1 molar ratio). The differential scanning calorimetry thermogram of the cocrystal showed a single and sharp endothermic peak at 110.49 °C. The cocrystal resulted in greater solubility and a faster dissolution rate of piperine than intact piperine. This improvement was a result of the formation of a channel structure in the cocrystal. In addition, the cocrystal was stable under a humid condition. |
| Databáze: | Directory of Open Access Journals |
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