Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
| Autor: | Sílvia H. Cardoso, João Vítor de Assis, Mauro V. de Almeida, Maria Cristina S. Lourenço, Felipe R. C. Vicente, Marcus V. N. de Souza |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 32, Iss 6, Pp 1557-1560 (2009) |
| Druh dokumentu: | article |
| ISSN: | 0100-4042 1678-7064 |
| DOI: | 10.1590/S0100-40422009000600038 |
| Popis: | A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL. Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis. |
| Databáze: | Directory of Open Access Journals |
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