| Autor: |
Jing TAO, Weilin LIU, Jia HUANG, Xiehua XUE, Shanli YANG, Yi ZHENG, Yunjiao LIN, Xiaoqian YE, Meiqin LIN, Lidian CHEN |
| Jazyk: |
English<br />Chinese |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
康复学报, Vol 25, Pp 23-34 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2096-0328 |
| DOI: |
10.13261/j.issn.2096-0328.2015.03.005 |
| Popis: |
Objective:To explore the effects and possible mechanisms of electroacupuncture (EA) at the Quchi (LI11) and Zusanli (ST36) acupints on the proliferation of endogenous neural stem cells in ischemic surrounding cortex and subventricular zone (SVZ) in ischemia-reperfusion injury rats, and then provide experimental basis for clinical application.Methods:Cerebral ischemia and reperfusion injury model was established by modified Zea Longa suture embolism. EA at Quchi and Zusanli of the affected limb for three days and seven days, the neurological deficit, infarct volume as well as the overall behavior of the animals were evaluated. The distribution of Nestin, Vimentin positive cells and co-labeled with Brdu were observed by immunohistochemistry and immuno-fluorescence. The expressions of proteins associated with Notch1 signaling pathway were detected by Western Blotting.Results:①The neurological deficit scores and infarct volume were reduced after EA at the Quchi and Zusanli acupints in ischemia-reperfusion injury rats (PPPPPPPPP>0.05). ⑤In the EA+GSI group, the number of Nestin positive cells and Brdu co-localized with Nestin in ischemic SVZ region were increased (PP |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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