Effectiveness and Safety of a Single-Dose Ivermectin Treatment for Uncomplicated Strongyloidiasis in Immunosuppressed Patients (ImmunoStrong Study): The Study Protocol

Autor: Fernando Salvador, Ana Lucas-Dato, Silvia Roure, Marta Arsuaga, Asunción Pérez-Jacoiste, Magdalena García-Rodríguez, José A. Pérez-Molina, Dora Buonfrate, José María Saugar, Israel Molina
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Pathogens, Vol 10, Iss 7, p 812 (2021)
Druh dokumentu: article
ISSN: 2076-0817
DOI: 10.3390/pathogens10070812
Popis: Strongyloidiasis affects an estimated 600 million people worldwide, especially in tropical and subtropical areas. Single-dose ivermectin treatment has shown to be effective among immunocompetent patients with uncomplicated strongyloidiasis. Here, we present the protocol of the ImmunoStrong study, a prospective observational study aiming to evaluate the effectiveness and safety of a single-dose ivermectin for treatment of uncomplicated strongyloidiasis in immunosuppressed patients. The secondary objectives are to assess accuracy of molecular techniques for the follow-up of these patients and to determine the population pharmacokinetics of ivermectin. The information retrieved by this study will cover relevant information gaps in the strongyloidiasis management among immunosuppressed patients.
Databáze: Directory of Open Access Journals