| Autor: |
Alberto Camacho, Juan Carlos Segoviano-Ramírez, Adriana Sánchez-Garcia, Jose de Jesus Herrera-de la Rosa, Jaime García-Juarez, Carlos Alberto Hernandez-Puente, Geovana Calvo-Anguiano, Sergio Rodolfo Maltos-Uro, Alejandra Olguin, Gabriel Gojon-Romanillos, Gabriel Gojon-Zorrilla, Rocio Ortiz-Lopez |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-11 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1476-511X |
| DOI: |
10.1186/s12944-018-0784-7 |
| Popis: |
Abstract Background Excessive subcutaneous adiposity in obesity is associated to positive white adipocyte tissue (WAT) differentiation (adipogenesis) and WAT expandability. Here, we hypothesized that supplementation with the insulin inhibitor and mitochondrial uncoupler, Tyrphostin (T-AG17), in vitro and in vivo inhibits adipogenesis and adipocyte hypertrophy. Methods We used a 3T3-L1 proadipocyte cell line to identify the potential effect of T-AG17 on adipocyte differentiation and fat accumulation in vitro. We evaluated the safety of T-AG17 and its effects on physiological and molecular metabolic parameters including hormonal profile, glucose levels, adipogenesis and adipocyte hypertrophy in a diet-induced obesity model using C57BL/6 mice. Results We found that T-AG17 is effective in preventing adipogenesis and lipid synthesis in the 3T3-L1 cell line, as evidenced by a significant decrease in oil red staining (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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