Genetic Characterization of Foot-and-Mouth Disease Viruses, Ethiopia, 1981–2007
| Autor: | Gelagay Ayelet, Mana Mahapatra, Esayas Gelaye, Berhe G. Egziabher, Tesfaye Rufeal, Mesfin Sahle, Nigel P. Ferris, Jemma Wadsworth, Geoffrey H. Hutchings, Nick J. Knowles |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 15, Iss 9, Pp 1409-1417 (2009) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid1509.090091 |
| Popis: | Foot-and-mouth disease (FMD) is endemic to sub-Saharan Africa. To further understand its complex epidemiology, which involves multiple virus serotypes and host species, we characterized the viruses recovered from FMD outbreaks in Ethiopia during 1981–2007. We detected 5 of the 7 FMDV serotypes (O, A, C, Southern African Territories [SAT] 1, and SAT 2). Serotype O predominated, followed by serotype A; type C was not recognized after 1983. Phylogenetic analysis of virus protein 1 sequences indicated emergence of a new topotype within serotype O, East Africa 4. In 2007, serotype SAT 1 was detected in Ethiopia and formed a new distinct topotype (IX), and serotype SAT 2 reappeared after an apparent gap of 16 years. The diversity of viruses highlights the role of this region as a reservoir for FMD virus, and their continuing emergence in Ethiopia will greatly affect spread and consequent control strategy of the disease on this continent. |
| Databáze: | Directory of Open Access Journals |
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