The efficacy and safety of sitagliptin administration in patients with Covid-19: A randomized clinical trial
| Autor: | Nahid Etemadi Toudeshki, Zahra Ameri Ahmad, Farzaneh Dastan, Elham Oveili, Arda Kiani, Atefeh Abedini, Ahad Zare |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Biomedical and Biotechnology Research Journal, Vol 7, Iss 2, Pp 260-264 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2588-9834 2588-9842 |
| DOI: | 10.4103/bbrj.bbrj_17_23 |
| Popis: | Background: Coronavirus disease was associated with a high risk of mortality, especially among patients with underlying diseases. Effective treatments against Covid-19 could complement vaccination efforts worldwide. Methods: To determine the efficacy of Sitagliptin in the treatment of COVID-19. Randomized clinical trial study with a control group that was conducted on 40 covidd-19 patients. Block randomization method was used. The participants were divided into two groups (group A receiving Sitagliptin tablet at dose of 50 mg BID for 10 days and the group B receiving standard treatment without sitagliptin). Descriptive statistics such as mean and standard deviation, ratio, frequency table and percentage were used to describe the data, and chi-square test, independent t test and one- way ANOVA were used to analyze the data. SPSS v. 25 software was used for data analysis. The significance level in the tests was considered 0.05. Results: A significant difference was observed between the improvements of the total clinical score in the two groups, so that the people who used Sitagliptin received a higher clinical score; On the other hand, among the 20 patients who were in the control group, 18 patients were discharged from the hospital on the 7th day or earlier. Sitagliptin has an anti-inflammatory, antifibrotic and antiapoptotic properties; such effects may be beneficial in reducing risks of COVID-19. Conclusions: Sitagliptin also provides good safety and fair benefits to reduce mortality among DM patients with COVID-19. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|