Comparative evaluation of therapy results in mild acne
| Autor: | I. M. Khismatulina, E. V. Faizullina, E. S. Gusarova, R. R. Nabieva |
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| Jazyk: | ruština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Медицинский совет, Vol 0, Iss 13, Pp 24-30 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2079-701X 2658-5790 |
| DOI: | 10.21518/2079-701X-2022-16-13-24-30 |
| Popis: | Introduction. Mild acne is the most underestimated form of the disease.The aim of the study was to compare the results of external combination therapy with 15% azelaic acid gel + 1% clindamycin gel and benzoyl peroxide + clindamycin for mild papulopustular acne.Material and methods. An open comparative prospective observational study in parallel groups (12 weeks) included 96 people, 65 patients with mild papulo-pustular acne and a control group of 30 healthy individuals. Group I received 15% azelaic acid gel +1% clindamycin gel, group II – benzoyl peroxide gel + clindamycin. The number of acne elements, morphofunctional indicators of the facial skin, side effects were recorded.Results. As a result of treatment, the indicators of sebumetry significantly decreased: in group I in the T-zone 47.5 ± 11.3 units (p = 0.043) and in the U-zone 57.5 ± 6.3 units (p = 0.037), and in group II in the T-zone 37.1 ± 5.8 units (p = 0.015) and in the U-zone 48.7 ± 5.6 units (p = 0.027). The pore sizes decreased significantly: in group I in the T-zone 0.052 ± 0.010 mm (p = 0.046) and in the U-zone 0.054 ± 0.009 mm (p = 0.049), and in group II in the T-zone 0.039 ± 0.011 mm (p = 0.064) and in the U-zone 0.047 ± 0.013 mm (p = 0.041). In patients in group I, pigmentation indicators in the T-zone of 17.0 ± 2.8 units (p ˂ 0.001) and the U-zone of 17.0 ± 2.8 units (p = 0.048) were normalized. In patients in both groups, there was a significant (p ˂ 0.05) decrease in the number of papulopustules.Conclusion. When comparing the results of therapy with 15% azelaic acid gel + 1% clindamycin gel and benzoyl peroxide + adapalene for mild papulopustular acne, comparable efficacy and safety were revealed. |
| Databáze: | Directory of Open Access Journals |
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