Hepcidin and Ferritin Levels in Fever of Unknown Origin: Is There a New Biomarker?
| Autor: | Ana Lopez Aparicio, Alejandro García-Espona-Pancorbo, Marta Clavero-Olmos, Inmaculada Muñoz-Roldán, Alejandro del Castillo-Rueda |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | European Journal of Case Reports in Internal Medicine, Vol 2, Iss 6 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2284-2594 72982314 |
| DOI: | 10.12890/2015_000240 |
| Popis: | Background and objectives: Significantly elevated serum ferritin levels are associated with both iron overload and some inflammatory conditions. Hepcidin is a protein that interferes with iron absorption in inflammatory states and acts as an acute-phase reactant. Materials and methods: Here we report the case a 33-year-old patient who presented with high fever, skin lesions and arthralgia lasting for 2 weeks. His ferritin level was 13,800 µg/l and his hepcidin level was 61 ng/dl. Results: The final diagnosis was adult onset Still's disease. The condition evolved satisfactorily with steroid treatment, but after several weeks the patient presented with an unexpected recurrence. Conclusions: Hepcidin is a good inflammatory marker that could be useful in the differential diagnosis of hyperferritinaemia. |
| Databáze: | Directory of Open Access Journals |
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