| Autor: |
Maria Barsan, Anca Monica Brata, Abdulrahman Ismaiel, Dinu Iuliu Dumitrascu, Andrei-Vlad Badulescu, Traian Adrian Duse, Stefana Dascalescu, Stefan Lucian Popa, Simona Grad, Lucian Muresan, Carmen Maria Maerescu, Gabriel Cismaru, Vlad Dumitru Brata |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Biomedicines, Vol 10, Iss 6, p 1239 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2227-9059 |
| DOI: |
10.3390/biomedicines10061239 |
| Popis: |
The global prevalence of vitamin D deficiency is more than 20%, and the main causes include insufficient intake, reduced absorption, abnormal metabolism, or resistance to its effects. The levels of serum vitamin D appear to influence cardiovascular risk, and the mechanism involved is linked to the transient outward current and the ultrarapid delayed rectifier K+ current densities, activated through the nuclear vitamin D receptor and Akt pathway. A significant number of studies have correlated vitamin D deficiency with an increased risk of developing cardiac arrhythmias and sudden cardiac death. For this reason, the purpose of this review is to analyze the relation between vitamin D deficiency and the pathogenesis of cardiac arrhythmias. Atrial fibrillation, increased QT interval, and QT dispersion were the most common findings associated with vitamin D deficiency. Due to the heterogeneity among existing studies, further research is necessary to confirm the existing data and to analyze its relationship with other types of arrhythmias. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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