| Autor: |
WU Mao-wang, SU Li, HE Fang, et al |
| Jazyk: |
čínština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Fayixue Zazhi, Vol 36, Iss 4, Pp 502-506 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1004-5619 |
| DOI: |
10.12116/j.issn.1004-5619.2020.04.014 |
| Popis: |
Objective To study the characteristics of positive expression of integrin β1 in the rat brain tissue of two kinds of traumatic brain injury models and to explore the feasibility of inferring the mode of traumatic brain injury using the positive expression of integrin β1. Methods The occipital region of rats was hit by hydraulic impact method and pendulum striking method to produce two closed brain injury models of linear and rotation acceleration respectively, then 120 SD rats were randomly divided into linear acceleration injury group, rotation acceleration injury group, sham operation group and normal control group. Immunohistochemistry staining and Western blotting method were used to detect the positive expression of integrin β1 in different parts of the brain tissue at 30 min, 3 h, 6 h, 12 h, 3 d and 7 d after rat injury. The data was processed statistically by SPSS 18.0 software. Results The positive expression of integrin β1 was detected 30 min after brain injury and reached the peak 6 h after brain injury. With the extension of injury time, the expression tended to enhance. At the same time points after injury, the differences in the positive expression of integrin β1 between the linear acceleration injury group and the rotation acceleration injury group in the occipital strike point and thalamus had no statistical significance （P>0.05）, but the differences in the expression of integrin β1 in the frontal lobe and brain stem had statistical significance （P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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