Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

Autor:	Haoyu He, Huaxiang Lu, Shuzhen Liu, Jiansheng Cai, Xu Tang, Chunbao Mo, Xia Xu, Quanhui Chen, Min Xu, Chuntao Nong, Qiumei Liu, Junling Zhang, Jian Qin, Zhiyong Zhang
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Hand grip strength Apolipoprotein E Single nucleotide polymorphism Gene-environment interaction Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Zdroj:	Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-7 (2021)
Druh dokumentu:	article
ISSN:	1749-799X
DOI:	10.1186/s13018-021-02522-2
Popis:	Abstract Background Hand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in Gongcheng, southern China. Methods APOE rs405509 polymorphisms in 1724 participants (695 men and 1029 women, aged 45–97 years old) were genotyped using the Sequenom MassARRAY platform. Statistical analysis was conducted using SPSS 21.0 and Plink 1.90. Results The APOE rs405509 G allele was associated with lower hand grip strength in all participants (β = −1.04, P value
Databáze:	Directory of Open Access Journals
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