Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients

Autor:	Mohammad Askari, Amin Reza Nikpoor, Hajar Aryan, Hamid Ghaedi, Javad Akhtari, Asaad Azarnejad, Kazem Mousavizadeh, Mohammad Hossein Sanati, Alireza Irani, Khalil Ghasemi Falavarjani, Hossein Nazari
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	age-related macular degeneration association study apolipoprotein E vision Medicine (General) R5-920
Zdroj:	Research in Molecular Medicine, Vol 3, Iss 2, Pp 22-27 (2015)
Druh dokumentu:	article
ISSN:	2322-1348 2322-133X
Popis:	Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development. Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distribution of polymorphic alleles and genotypes of this gene in the sample population. Results: The frequency distribution of APOE alleles and genotypes differed significantly between the patients and the control groups (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0298d2e7d25d45269df4daa005d759fe Zobrazit plný text záznamu View record in DOAJ