| Autor: |
Christoffer S. Graven-Nielsen, Ida.V. Vittrup, Anna J. Kragh, Fredrik Lund, Sofie Bliddal, MD, PhD, Kristian Kofoed, MD, PhD, Salome Kristensen, MD, PhD, Allan Stensballe, PhD, Claus H. Nielsen, MD, MsC, PhD, Ulla Feldt-Rasmussen, MD, DMSc, René Cordtz, MD, PhD, Lene Dreyer, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
JAAD International, Vol 13, Iss , Pp 126-133 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3287 |
| DOI: |
10.1016/j.jdin.2023.07.018 |
| Popis: |
Background: Polyautoimmunity is defined as having 2 or more autoimmune diseases. Little is known about polyautoimmunity in patients with cutaneous lupus erythematosus (CLE). Objectives: To estimate prevalence and 5-year incidence of non–lupus erythematosus (LE) autoimmune diseases in patients with CLE. Methods: Patients with CLE were identified In the Danish National Patient Registry and each patient was age- and sex-matched with 10 general population controls. Outcome information on non-LE autoimmune diseases was obtained by register-linkage between Danish National Patient Registry and the National Prescription Register. The risk ratio (RR) for prevalent non-LE autoimmune disease at time of CLE diagnosis was calculated in modified Poisson regression; and hazard ratios (HRs) for incident non-LE autoimmune disease were estimated in Cox regression analyses. Results: Overall, 1674 patients with CLE had a higher prevalence of a non-LE autoimmune disease than the comparators (18.5 vs 7.9%; RR 2.4; 95% CI, 2.1 to 2.6). Correspondingly, the cumulative incidence of a non-LE autoimmune disease during 5 years of follow-up was increased for the patients with CLE: HR 3.5 (95% CI, 3.0 to 4.0). Limitations: Risk of detection and misclassification bias, mainly pertaining to the CLE group. Conclusion: Patients with CLE had higher prevalence and 5-year cumulative incidence of a non-LE autoimmune disease than the general population. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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