PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development

Autor: Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica K. Evans, Meritxell Alberich-Jordà, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03888-7
Popis: The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and c-Jun have defects in PU.1 dependent blood lineages, including macrophages and B cells.
Databáze: Directory of Open Access Journals
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