| Autor: |
Mengchu Zhang, Yukai Li, Yuwei Wang, Jirong Shu, Tianyuan Zhang, Dan Zhang, Song Cai, Taoda Shi, Wenhao Hu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Green Synthesis and Catalysis, Vol 5, Iss 3, Pp 180-185 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5549 |
| DOI: |
10.1016/j.gresc.2023.04.006 |
| Popis: |
We herein reported a sustainable synthesis of 3,3-disubstituted oxindoles via a Michael-type reaction based on the CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile. The reaction is characterized by a high atom economy and low economic constraints. The catalyst CuBr could be conveniently recyclized. The products of the reaction were found to be inhibitory against Na ion channels. We expect the reaction to shed the light on synthesis of biologically interesting molecules directed by principles of green chemistry. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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