Changes of circulating anti-A/B-antibody titers during the preparation period and after AB0-incompatible living donor kidney transplantation
| Autor: | A. I. Sushkov, Ya. G. Moisyuk |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Трансплантология (Москва), Vol 0, Iss 2-3, Pp 48-53 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2074-0506 2542-0909 |
| DOI: | 10.23873/2074-0506-2011-0-2-3-48-53 |
| Popis: | Several protocols have been developed to overcome the blood group barrier in renal transplantation. In the evolution of these protocols, one of the latest steps was the combination of anti-CD20 treatment with antigen-specific immunoadsorption (IA) and intravenous immunoglobulin (IvIg). This protocol has been widespread used for AB0-incompatible transplantation in Europe. We report our first experience of five successful AB0-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. Initial anti-A/B-antidody titers were 1:16 to 1:1024. The transplantation could be performed in all cases and the grafts showed primary function. |
| Databáze: | Directory of Open Access Journals |
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