| Autor: |
Damian Bruce-Hickman, Shanaz Matthew Sajeed, Yin Huei Pang, Choon Sheong Seow, Weihao Chen, Monika Gulati Kansal |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
BMJ Open Gastroenterology, Vol 7, Iss 1 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2054-4774 |
| DOI: |
10.1136/bmjgast-2020-000484 |
| Popis: |
Tocilizumab, a monoclonal antibody against interleukin-6, has been used to treat cytokine release syndrome (CRS) in a subset of patients with severe COVID-19 disease. Acute ulcerative bowel disease has been only rarely documented in patients treated for rheumatological conditions. The gastrointestinal side effects seen when used in the context of COVID-19 are unknown. We present a case of COVID-19 CRS in which acute terminal ileum and perforated caecal ulceration evolved after tocilizumab exposure. We raise awareness of a possible causal relationship between even a single dose of tocilizumab and gut ulceration in patients with COVID-19. Any such drug enteropathy relationship requires watchful monitoring during upcoming trials of tocilizumab in patients with COVID-19. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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