Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1

Autor: O'Sullivan Brendan, Bramhall Simon, Alabraba Edward, Mahon Brinder, Taniere Philippe
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: World Journal of Surgical Oncology, Vol 7, Iss 1, p 18 (2009)
Druh dokumentu: article
ISSN: 1477-7819
DOI: 10.1186/1477-7819-7-18
Popis: Abstract Background Gastrointestinal stromal tumours (GIST) frequently occur in patients with neurofibromatosis type 1 (NF-1). It has been reported that GIST may co-exist with pancreatic endocrine tumors but this has only been in association with NF-1. Case presentation A 76 year old woman presented with a 12 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated a 13 mm insulinoma localized in the tail of her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small (< 1 cm) incidental tumour was discovered on her stomach wall which was identified as GIST. Conclusion This is the first case report of a pancreatic insulinoma co-existing with a GIST in a patient without NF-1. In addition, we make the first report of rapidly growing cystic GIST recurrence following resection of a primary GIST tumour.
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