Cost-effectiveness of stepwise provisional versus systematic dual stenting strategies in patients with distal bifurcation left main stem lesions: economic analysis of the EBC MAIN trial

Autor: Isabelle Durand-Zaleski, Mohaned Egred, Adrian P Banning, David Hildick-Smith, Marie-Claude Morice, Philippe Brunel, Alicia Le Bras, Arnaud Nze Ossima, Olivier Supplisson
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Open Heart, Vol 11, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2053-3624
DOI: 10.1136/openhrt-2023-002479
Popis: Background In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting.Aims To estimate the 1-year cost-effectiveness of stepwise provisional versus systematic dual stenting strategies.Methods Costs in France and the UK, and MACE were calculated in both groups to estimate the incremental cost-effectiveness ratio (ICER). Uncertainty was explored by probabilistic bootstrapping. The analysis was conducted from the perspective of the healthcare provider with a time horizon of 1 year.Results The cost difference between the two groups was €−755 (€5700 in the stepwise provisional group and €6455 in the systematic dual stenting group, p value
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