| Autor: |
Chaiwat Washirasaksiri, Naruemit Sayabovorn, Pinyapat Ariyakunaphan, Chayanis Kositamongkol, Thanet Chaisathaphol, Tullaya Sitasuwan, Rungsima Tinmanee, Chonticha Auesomwang, Pongpol Nimitpunya, Diana Woradetsittichai, Methee Chayakulkeeree, Pakpoom Phoompoung, Korapat Mayurasakorn, Nitat Sookrung, Anchalee Tungtrongchitr, Rungsima Wanitphakdeedecha, Saipin Muangman, Sansnee Senawong, Watip Tangjittipokin, Gornmigar Sanpawitayakul, Cherdchai Nopmaneejumruslers, Visit Vamvanij, Pochamana Phisalprapa, Weerachai Srivanichakorn |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-41523-5 |
| Popis: |
Abstract Few studies have identified the metabolic consequences of the post-acute phase of nonsevere COVID-19. This prospective study examined metabolic outcomes and associated factors in nonsevere, RT-PCR-confirmed COVID-19. The participants’ metabolic parameters, the prevalence of long-term multiple metabolic abnormalities (≥ 2 components), and factors influencing the prevalence were assessed at 1, 3, and 6 months post-onset. Six hundred individuals (mean age 45.5 ± 14.5 years, 61.7% female, 38% high-risk individuals) with nonsevere COVID-19 attended at least one follow-up visit. The prevalence of worsening metabolic abnormalities was 26.0% for BMI, 43.2% for glucose, 40.5% for LDL-c, 19.1% for liver, and 14.8% for C-reactive protein. Except for lipids, metabolic-component abnormalities were more prevalent in high-risk hosts than in healthy individuals. The prevalence of multiple metabolic abnormalities at the 6-month follow-up was 41.3% and significantly higher in high-risk than healthy hosts (49.2% vs 36.5%; P = 0.007). Factors independently associated with a lower risk of these abnormalities were being female, having dyslipidemia, and receiving at least 3 doses of the COVID-19 vaccine. These findings suggest that multiple metabolic abnormalities are the long-term consequences of COVID-19. For both high-risk and healthy individuals with nonsevere COVID-19, healthcare providers should monitor metabolic profiles, encourage healthy behaviors, and ensure complete vaccination. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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