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Leslie O’Dell,1 Damon S Dierker,2 Douglas K Devries,3 Jaclyn Garlich,4 Walter O Whitley,5 Mark Holdbrook,6 Stephanie N Baba,6 Elizabeth Yeu5 1Medical Optometry America, Shrewsbury, PA, USA; 2Eye Surgeons of Indiana, Indianapolis, IN, USA; 3Eye Care Associates of Nevada, Sparks, NV, USA; 4Envision Optometry, Boston, MA, USA; 5Virginia Eye Consultants, Norfolk, VA, USA; 6Tarsus Pharmaceuticals, Inc, Irvine, CA, USACorrespondence: Elizabeth Yeu, Virginia Eye Consultants, 241 Corporate Boulevard, Suite 210, Norfolk, VA, 23502, USA, Tel +1 757 793 4942, Fax +1 757 319 2493, Email eyeulin@gmail.comPurpose: To evaluate the impact of Demodex blepharitis on patients’ daily activities and quality of life.Patients and Methods: In this multicenter, observational, prospective, IRB-approved study, 311 Demodex blepharitis patients aged ≥ 18 years were included. Demodex blepharitis was diagnosed based on the presence of ≥ 1.0 mite per lash (upper and lower eyelids combined), > 10 collarettes on the upper lashes, and at least mild lid margin erythema of the upper eyelid in at least one eye. All patients were asked to complete a questionnaire about their symptoms, daily activities, quality of life, and management approaches, and descriptive statistics were used to analyze the responses.Results: More than half the patients had been experiencing symptoms of blepharitis for ≥ 4 years. The three most frequent and bothersome symptoms experienced by patients were dry eyes, itchiness, and irritation. Nearly half the patients (47%) responded that they were conscious of their eyes all day, and 23% said that they were constantly worrying about their eyes. Other activities that were negatively affected included difficulty driving at night (47%), additional time needed for daily hygiene routine (30%), and difficulty in wearing eye make-up (in 34% of females). While all subjects had objective signs of Demodex blepharitis confirmed by an eye care provider, 58% said they had never previously been diagnosed with blepharitis. The most commonly used management approaches for Demodex blepharitis were artificial tears (47%), warm compresses (32%), and lid wipes (14%).Conclusion: Demodex blepharitis has a significant negative impact on daily activities and the mental and physical well-being of afflicted patients.Keywords: Demodex blepharitis, dry eye disease, collarettes, cylindrical dandruff, Demodex mites, lid margin disease |
