Silver nanoparticles modulate high fat high carbohydrate diet induced metabolic changes in rats via reducing lipid peroxidation, PDGF-β and insulin resistance

Autor:	Mahmoud Ashri, Nashwa Abu-Elsaad, Tarek Ibrahim
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	fatty liver insulin resistance nanoparticles silver Medicine (General) R5-920
Zdroj:	Nanomedicine Journal, Vol 9, Iss 4, Pp 296-306 (2022)
Druh dokumentu:	article
ISSN:	2322-3049 2322-5904 82537542
DOI:	10.22038/nmj.2022.67356.1712
Popis:	Objective(s): Non-alcoholic fatty liver disease (NAFLD) is strongly linked with insulin resistance and type-2 diabetes through various metabolic changes. The current study was designed to investigate the modulatory effects of silver nanoparticles (AgNPs) on metabolic and inflammatory changes activated during NAFLD. Materials and Methods: Three doses of AgNPs (100, 150, and 200 μg/kg/day for 4 weeks) were tested in a high-fat high carbohydrate diet (HFHCD) induced NAFLD model in rats. Results: Sinificant (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/023ec6c5e7cf43f0abcd997a82537542 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF