Identification of modified peptides using localization-aware open search

Autor: Fengchao Yu, Guo Ci Teo, Andy T. Kong, Sarah E. Haynes, Dmitry M. Avtonomov, Daniel J. Geiszler, Alexey I. Nesvizhskii
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17921-y
Popis: Mass spectrometry-based proteomics is the method of choice for the global mapping of post-translational modifications, but matching and scoring peaks with unknown masses remains challenging. Here, the authors present a refined open search strategy to score all peaks with higher sensitivity and accuracy.
Databáze: Directory of Open Access Journals