Research advances Progress in mechanistic studies of renal fibrosis based upon regulatory cell death

Autor: Sheng Zhong, Jing Tan, Zhi-jun Deng, Jin-rong Wang, Guang-ming Yin, Xian-zhen Jiang
Jazyk: čínština
Rok vydání: 2024
Předmět:
Zdroj: Linchuang shenzangbing zazhi, Vol 24, Iss 11, Pp 956-961 (2024)
Druh dokumentu: article
ISSN: 1671-2390
DOI: 10.3969/j.issn.1671-2390.2024.11.011
Popis: As a basic pathological feature at advanced stage of various kidney diseases, renal fibrosis (RF) is an important cause of kidney failure. It is characterized by an excessive accumulation of extracellular matrix (ECM), damage of renal tissue structure and loss of renal function. Regulated cell death (RCD) is closely correlated with RF since it involves a signaling cascade involving effector molecules. This review summarized the mechanism of RCD involved in the progression of RF and provided references for clinical treatment of RF.
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