Endocrine Disrupting Chemicals in Polycystic Ovary Syndrome: The Relevant Role of the Theca and Granulosa Cells in the Pathogenesis of the Ovarian Dysfunction

Autor:	Malgorzata Jozkowiak, Hanna Piotrowska-Kempisty, Dominik Kobylarek, Natalia Gorska, Paul Mozdziak, Bartosz Kempisty, Dominik Rachon, Robert Z. Spaczynski
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	polycystic ovary syndrome granulosa cells theca cells endocrine disrupting chemicals Cytology QH573-671
Zdroj:	Cells, Vol 12, Iss 1, p 174 (2022)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells12010174
Popis:	Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder among women of reproductive age. The pathogenesis of PCOS remains elusive; however, there is evidence suggesting the potential contribution of genetic interactions or predispositions combined with environmental factors. Among these, endocrine disrupting chemicals (EDCs) have been proposed to potentially contribute to the etiology of PCOS. Granulosa and theca cells are known to cooperate to maintain ovarian function, and any disturbance can lead to endocrine disorders, such as PCOS. This article provides a review of the recent knowledge on PCOS pathophysiology, the role of granulosa and theca cells in PCOS pathogenesis, and the evidence linking exposure to EDCs with reproductive disorders such as PCOS.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/0228016d0d6b468eb345fae80305255c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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