Extensive Mucosal Erosion and Sloughing of Tongue: A Hitherto Unknown Complication of Topical Clotrimazole Preparation
| Autor: | Mainak Dutta, Soumya Ghatak, Gautam Biswas, Ramanuj Sinha |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Journal of Nepal Medical Association, Vol 52, Iss 189, Pp 277-280 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0028-2715 1815-672X |
| Popis: | Clotrimazole, a broad-spectrum imidazole antimycotic, is a widely-used prescription as well as an over-the-counter drug for treatment of mucosal (oral, vulvovaginal) candidiasis and dermatophytes. An extremely safe and well-tolerated drug, its safety profile has been well-explored in researches and trials. The commonest complaints are almost always non-serious-pruritus, rashes, paraesthesia (stinging/burning sensation) and erythema on topical applications, and nausea, vomiting, unpleasant taste sensation and elevated liver enzymes on oral preparations (troches). However, mucosal ulceration on topical clotrimazole preparation has not been reported in literature before. We present here the first documentation of extensive bilateral erosions and necrosis of tongue involving the mucosa, submucosa and musculature on application of one percent weight/volume clotrimazole mouth paint in a 27-year-old immunocompetent woman who presented with oral candidiasis. Keywords: extensive bilateral ulceration and necrosis; oral candidiasis; side effect; topical clotrimazole. |
| Databáze: | Directory of Open Access Journals |
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