MELATONIN: PERSPECTIVES IN THERAPY OF DIFFERENT PSYCHIATRIC DISORDERS (A LITERATURE REVIEW)
| Autor: | Angelina Nailevna Hannanova, Yuriy Vitalevich Bykov, Roman Aleksandrovich Bekker |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | В мире научных открытий, Vol 9, Iss 1, Pp 131-149 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2072-0831 2307-9428 |
| DOI: | 10.12731/wsd-2017-1-131-149 |
| Popis: | Purpose. To review all the existing evidence base regarding the use of melatonin in therapy of different mental diseases, to formulate conclusions on the quality of existing evidence, on melatonin’s perspectives in this regard and on the feasibility of future research on its usefulness in psychiatry. Methodology. We performed a full text search in several publicly accessible biomedical databases, namely PubMed / MedLine / EmBASE / UpToDate, using keyword “melatonin” in conjunction with keywords “cognition”, “cognitive”, “mood disorders”, “affective disorders”, “insomnia”, “psychosis”, “schizophrenia”, “anxiety disorders”. All results we had found were then analyzed and sorted by the strongness of evidence presented (RCTs, open prospective trials, case series, single cases, untested expert opinions and theoretical hypotheses). Then we made conclusions based on the evidence presented. Results. Results we have obtained in this literature review show that melatonin can be useful as a component of combination therapy in insomnias, depressions, schizophrenia and other psychoses, anxiety disorders, and can be helpful in prophylactics or treatment of some side effects of psychopharmacotherapy, namely metabolic syndrome, akathisia, tardive dyskinesias, insomnias. Practical implications. Our results deserve wide clinical application in the field of psychiatry, substance use medicine and neurology. |
| Databáze: | Directory of Open Access Journals |
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