| Autor: |
Ian T. Stancil, Jacob E. Michalski, Duncan Davis-Hall, Hong Wei Chu, Jin-Ah Park, Chelsea M. Magin, Ivana V. Yang, Bradford J. Smith, Evgenia Dobrinskikh, David A. Schwartz |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-021-24853-8 |
| Popis: |
Environmental and genetic risk factors affect the distal airway epithelium in idiopatic pulmonary fibrosis (IPF) but the role of the epithelium in IPF remains unclear. Here the authors show that pathologic activation of the ERBB-YAP axis induces dynamic and structural dysfunction in the distal airway epithelium eliciting a pro-fibrotic phenotype in mesenchymal cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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