Blastocystis incidence, spontaneous clearance, persistence and risk factors in a rural community in Thailand: A prospective cohort study

Autor: Kawin Wongthamarin, Thanaporn Trairattanapa, Sirakit Kijanukul, Thanakrit Kritsilpe, Sarun Poobunjirdkul, Warit Chuengdee, Mathirut Mungthi, Saovanee Leelayoova, Tawee Naaglor, Paanjit Taamasri, Picha Suwannahitatorn, Toon Ruang-Areerate, Phunlerd Piyaraj
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 3, Pp 123-130 (2020)
Druh dokumentu: article
ISSN: 2352-4146
1995-7645
DOI: 10.4103/1995-7645.278097
Popis: Objective: To investigate the incidence, spontaneous clearance, persistence and risk factors of Blastocystis infection in a rural community in Thailand. Methods: In February 2016, a cohort study was conducted in a rural community of Thailand. Baseline information of intestinal parasitic infections and follow-up visits were conducted. Blastocystis infection was detected in stool samples examined with short-term in vitro cultivation using Jones’ medium supplemented with 10% horse serum. Participants were tested for Blastocystis infection at every study visit. Cox proportional hazard regression analysis was used to evaluate co-variates to determine the incidence of Blastocystis infection. Results: Of 733 enrolled participants, 57 (7.78%) were positive and 676 (92.22%) were negative for Blastocystis infection. All 676 participants were followed-up for Blastocystis infection between December 2016 and January 2018. In all, 52 of 482 cases (10.79%) comprised individual Blastocystis infection. The incidence density rates of Blastocystis infection, of spontaneous clearance of the disease and of persistent infection were 8.13, 63.14 and 38.70 per 1 000 person-months of follow-up, respectively. Our multivariate analysis revealed that opened defecation in fields or bushes (HR=4.8; 95% CI =2.1-10.4, P
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