Anti-Tumor Secondary Metabolites Originating from Fungi in the South China Sea’s Mangrove Ecosystem

Autor: Yuyou Luo, Xiongming Luo, Tong Zhang, Siyuan Li, Shuping Liu, Yuxin Ma, Zongming Wang, Xiaobao Jin, Jing Liu, Xin Wang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Bioengineering, Vol 9, Iss 12, p 776 (2022)
Druh dokumentu: article
ISSN: 2306-5354
DOI: 10.3390/bioengineering9120776
Popis: A mangrove is a unique ecosystem with abundant resources, in which fungi are an indispensable microbial part. Numerous mangrove fungi-derived secondary metabolites are considerable sources of novel bioactive substances, such as polyketides, terpenoids, alkaloids, peptides, etc., which arouse people’s interest in the search for potential natural anti-tumor drugs. This review includes a total of 44 research publications that described 110 secondary metabolites that were all shown to be anti-tumor from 39 mangrove fungal strains belonging to 18 genera that were acquired from the South China Sea between 2016 and 2022. To identify more potential medications for clinical tumor therapy, their sources, unique structures, and cytotoxicity qualities were compiled. This review could serve as a crucial resource for the research status of mangrove fungal-derived natural products deserving of further development.
Databáze: Directory of Open Access Journals
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